2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133115S
    N-Desmethylnefopam-d5 2748500-28-7
    N-Desmethylnefopam-d5 is the deuterium labeled N-Desmethylnefopam (HY-133115). N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.
    N-Desmethylnefopam-d5
  • HY-133153S
    Fenpiverinium-d3 bromide 99.46%
    Fenpiverinium-d3 (bromide) is a deuterium labeled Fenpiverinium bromide. Fenpiverinium bromide has anti-cholinergic and anti-spasmodic effects.
    Fenpiverinium-d3 bromide
  • HY-134458A
    H-Lys-Tyr-OH TFA 98%
    H-Lys-Tyr-OH TFA (Lysyltyrosine TFA) is a dipeptide composed of lysine and tyrosine. H-Lys-Tyr-OH TFA prevents neurological diseases or improves brain function by promoting the release of noradrenaline and tyrosine into the brain.
    H-Lys-Tyr-OH TFA
  • HY-13458S1
    Droxidopa-13C2,15N hydrochloride 1329556-63-9 98%
    Droxidopa-13C2,15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier.
    Droxidopa-13C2,15N hydrochloride
  • HY-134894A
    Glycerophosphorylethanolamine sodium 883288-78-6 98%
    Glycerophosphorylethanolamine (GroPEtn) sodium is an active phosphodiester metabolite of Phosphatidylethanolamine (HY-W250118). Glycerophosphorylethanolamine sodium promotes the aggregation of amyloid β-protein (Aβ (1-40)) in vitro. Glycerophosphorylethanolamine sodium can be used in the field of neurodegenerative diseases, such as Alzheimer’s disease research.
    Glycerophosphorylethanolamine sodium
  • HY-135006A
    Octahydroaminoacridine 13415-07-1 98%
    Octahydroaminoacridine, a Tacrine analogue, is an acetylcholinesterse (AChE) and butyrylcholinesterase (BChE) inhibitor. Octahydroaminoacridine can be used for Alzheimer's disease (AD) research.
    Octahydroaminoacridine
  • HY-135094R
    Palmitoyl glutamic acid (Standard) 38079-66-2
    Palmitoyl glutamic acid (Standard) is the analytical standard of Palmitoyl glutamic acid. This product is intended for research and analytical applications. Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) is an acyl amino acid with neuroprotective effects[1]. Palmitoyl glutamic acid is used as cosmetic material[2].
    Palmitoyl glutamic acid (Standard)
  • HY-135359R
    RP 48497 (Standard) 148891-53-6
    Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
    RP 48497 (Standard)
  • HY-135392R
    N-Desmethyl Pimavanserin (Standard) 639863-77-7
    Methyl 3,4-dihydroxybenzoate (Standard) is the analytical standard of Methyl 3,4-dihydroxybenzoate. This product is intended for research and analytical applications. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.
    N-Desmethyl Pimavanserin (Standard)
  • HY-135392S
    N-Desmethyl Pimavanserin-d9 hydrochloride 2712363-60-3 98%
    N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
    N-Desmethyl Pimavanserin-d9 hydrochloride
  • HY-135507A
    NAS-181 free base 205242-61-1 98%
    NAS181 free base is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 free base shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 free base increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.
    NAS-181 free base
  • HY-135761R
    Penconazole (Standard) 66246-88-6
    Penconazole (Standard) is the analytical standard of Penconazole. This product is intended for research and analytical applications. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole (Standard)
  • HY-135880A
    OMDM-4 616884-65-2 98%
    OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki 17.7 μM.
    OMDM-4
  • HY-136109E
    SEP-363856 mesylate 2375116-27-9 98%
    SEP-363856 (SEP-856) mesylate, an orally active TAAR1 and 5-HT1A agonist and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 mesylate has the potential for the study of schizophrenia.
    SEP-363856 mesylate
  • HY-136299A
    Sepimostat dimethanesulfonate 103926-82-5 98%
    Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 µM.
    Sepimostat dimethanesulfonate
  • HY-136341R
    7,8-Dihydroneopterin (Standard) 1218-98-0
    Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
    7,8-Dihydroneopterin (Standard)
  • HY-136520S
    Xanthoanthrafil-d3 1216710-83-6 98%
    Xanthoanthrafil-d3 is the deuterium labeled Xanthoanthrafil (HY-136520B). Xanthoanthrafil is a potent phosphodiesterase-5 (PDE5) inhibitor, with an IC50 of 3.95 ng/mL. Xanthoanthrafil can be used for the research of erectile dysfunction.
    Xanthoanthrafil-d3
  • HY-136564A
    DAD 98%
    DAD is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD is a third-generation photoswitch that responds to visible light. DAD has the potential for restoring visual function.
    DAD
  • HY-136678A
    SB 258741 hydrochloride 98%
    SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia.
    SB 258741 hydrochloride
  • HY-137040A
    Tiemonium iodide 144-12-7 98%
    Tiemonium iodide is a mAChR antagonist with antispasmodic properties. Tiemonium iodide can be used in nervous system research.
    Tiemonium iodide
Cat. No. Product Name / Synonyms Application Reactivity